Fig. 2
A possible model of cell fate decisions in GCs. The relative affinity of a GCBC’s BCR for an antigen influences the strength and duration of positively selecting signals (signals from BCR and TFH cells) and may instruct cell fate decisions along the axis: death (absence of positively selecting signals) < GCMBC differentiation < DZ reentry < GCPC differentiation (top). However, the exact boundaries between these outcomes are likely to be strongly blurred by stochastic events in the GC environment (bottom)
