Fig. 2: Transcriptional regulators of TSL, eff-like TEX, and TEX-term. | Cellular & Molecular Immunology

Fig. 2: Transcriptional regulators of TSL, eff-like TEX, and TEX-term.

From: Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy

Fig. 2: Transcriptional regulators of TSL, eff-like TEX, and TEX-term.

Development and/or maintenance of TSL is driven by transcription factors such as TCF1, BACH2, MYB, FOXP1, FOXO1, ID3, BCL6, c-JUN, and SATB1. The transcription factors BATF, IRF4, ID2, and RUNX3 promote the terminal differentiation of CD8 T cells and suppress stem-like cell fate. Among the terminally differentiated subsets, the eff-like TEX subset is positively regulated by KLF2, ZEB2, T-BET, and BHLHE40, whereas NR4A and BLIMP1 promote terminal exhaustion. Both the TSL and TEX-Term lineages require TOX

Back to article page