Fig. 1: Architecture of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and highly accurate 3D protein structure prediction with AI.
From: Dive into soft matter imaging: artificial intelligence-integrated electron microscopy
a Hierarchical, complex assembly of proteins into SARS-CoV-21. Ultrastructure of the ribonucleoprotein (RNP), RNP hexagon with representative tomogram slices (left) and a whole virion visualized through a cryogenic transmission electron micrograph (right). b Spikes of SARS-CoV-2 showing the refined orientation of the prefusion and postfusion conformations as a representative molecular machinery system. Reproduced with permission from ref.1. Copyright 2020 Cell Press. c AI-predicted protein structure: Intertwined homotrimer (PDB 6SK0) predicted by AlphaFold (left). Protein-protein interactions of PDB 7T82 predicted by AlphaFold 3 and evaluation of the experimental accuracy (right). The structures are colored by pLDDT (predicted local distance difference test) and by chain. DockQ interface scores and predicted aligned error (PAE) matrix are shown to indicate prediction accuracy and confidence9,10. Reproduced with permission from refs. 9,10. Copyright 2021, 2024 Springer Nature.
