Fig. 6

Proximity labeling with mutation analysis. A Targets of RNA-binding proteins identified by editing (TRIBE). The catalytic domain of the ADAR RNA-editing enzyme converts adenosine to inosine in bound RNAs. Inosine is read as guanosine during sequencing. B Oxidation-induced nucleotide conversion (OINC)-Seq. The ROS generated by DBF oxidize guanine, leading to nucleotide misincorporations or deletions during reverse transcription