Table 3 In vitro antibacterial activities (Inhibition rate/%) of the azole antifungals drugs against phytopathogenic bacteria
From: Drug repurposing strategy part 1: from approved drugs to agri-bactericides leads
Compounds | Concentration (μg ml−1) | Inhibition rate/% | ||
|---|---|---|---|---|
Xoo | Xac | Pa | ||
Ketoconazole | 100 | 15.95 ± 6.27 | 13.31 ± 0.31 | 0 ± 0 |
Bifonazole | 100 | 96.58 ± 2.28 | 8.67 ± 2.79 | 13.46 ± 3.44 |
Clotrimazole | 100 | 100 ± 0 | 97.83 ± 0 | 13.46 ± 3.44 |
Fluconazole | 100 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
Voriconazole | 100 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
Sulconazle Nitrate | 100 | 100 ± 0 | 97.52 ± 0.62 | 83.04 ± 0.64 |
Vagistat | 100 | 97.72 ± 0.57 | 97.21 ± 0.31 | 0 ± 0 |
Butoconazole nitrate | 100 | 100 ± 0 | 99.07 ± 0.31 | 0 ± 0 |
Terconazole | 100 | 78.63 ± 4.84 | 43.65 ± 3.41 | 4.65 ± 1.5 |
Efinaconazole | 100 | 71.51 ± 0 | 50.46 ± 0.31 | 10.88 ± 3.22 |
Isoconazole nitrate | 100 | 97.72 ± 1.71 | 92.57 ± 0.31 | 8.95 ± 2.03 |
Fenticonazole nitrate | 100 | 98.86 ± 5.98 | 86.69 ± 0.62 | 46.96 ± 5.46 |
Elubiol | 100 | 92.59 ± 3.99 | 62.54 ± 8.67 | 0 ± 0 |
Miconazole | 100 | 97.48 ± 0.13 | 63.72 ± 2.12 | 7.09 ± 2.12 |
Itraconazole | 100 | 26.68 ± 1.92 | 21 ± 9.99 | 29.5 ± 13.94 |
Econazole | 100 | 100 ± 0 | 100 ± 0 | 50.11 ± 2.12 |
Posaconazole | 100 | 14.64 ± 4.92 | 0.48 ± 12.53 | 16.72 ± 3.87 |
Isavuconazole | 100 | 100 ± 0 | 55.89 ± 2.58 | 86.47 ± 5.15 |
Luliconazole | 100 | 95.62 ± 2.79 | 36.29 ± 1.03 | 6.6 ± 10.63 |
letrozole | 100 | 25.6 ± 3.98 | 15.65 ± 11.61 | 67.79 ± 4.35 |
Atipamezole hydrochloride | 100 | 92.1 ± 0.29 | 96.52 ± 0.95 | 0 ± 0 |
Anastrozole | 100 | 27.59 ± 6.76 | 7.91 ± 2.84 | 6.92 ± 2.74 |
InterMediate of Linezolid | 100 | 0 ± 0 | 15.01 ± 1.45 | 0 ± 0 |
(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate | 100 | 100 ± 0 | 20.82 ± 0.73 | 0 ± 0 |
Rivaroxaban | 100 | 12.01 ± 9.67 | 20.1 ± 6.54 | 0 ± 0 |
Methazolamide | 100 | 0 ± 0 | 0 ± 0 | 0 ± 0 |
Valsartan | 100 | 0 ± 0 | 23.02 ± 5.32 | 0 ± 0 |
Deracoxib | 100 | 9.73 ± 1.92 | 92.44 ± 0.56 | 29.25 ± 5.18 |
Benzydamine hydrochloride | 100 | 45.84 ± 0.19 | 76.75 ± 0.28 | 13.04 ± 0 |
2-Benzoxazolinone | 100 | 3.01 ± 4.99 | 29.69 ± 0.28 | 100 ± 0 |
Deferasirox | 100 | 81.27 ± 1.46 | 68.99 ± 3.48 | 0 ± 0 |
Cilostazol | 100 | 9.23 ± 2.8 | 0 ± 0 | 0.67 ± 0.84 |
topiroxostat | 100 | 68.57 ± 4.38 | 25.71 ± 8.83 | 0 ± 0 |
Levamisole hydrochloride | 100 | 34.7 ± 1.99 | 35.92 ± 11.65 | 15.25 ± 7.51 |
Temozolomide | 100 | 25.06 ± 5.32 | 17.92 ± 3.63 | 0 ± 0 |
Celecoxib | 100 | 85.01 ± 0 | 0 ± 0 | 0 ± 0 |
Flubendazole | 100 | 86.87 ± 1.09 | 16.65 ± 7.99 | 79.08 ± 8.52 |
Mebendazole | 100 | 100 ± 0 | 1.8 ± 21.35 | 19.41 ± 11.66 |
Oxibendazole | 100 | 100 ± 0 | 65.69 ± 3.81 | 13.68 ± 0.64 |
Fenbendazole | 100 | 99.44 ± 0.28 | 54.05 ± 4.62 | 0.44 ± 19.53 |
Albendazole | 100 | 68.26 ± 1.95 | 15.12 ± 1.34 | 3.35 ± 2.92 |
Omeprazole | 100 | 33.57 ± 2.13 | 48.95 ± 22.17 | 31.29 ± 1.86 |
Esomeprazole magnesium | 100 | 32.15 ± 2.84 | 52.56 ± 1.29 | 63.87 ± 4.22 |
Ufiprazole | 100 | 18.29 ± 0 | 38.12 ± 4.38 | 39.05 ± 2.36 |
Lansoprazole | 100 | 54.53 ± 0.36 | 78.34 ± 0.52 | 61.51 ± 3.04 |
lansoprazole sulfide | 100 | 16.87 ± 1.78 | 11.82 ± 1.29 | 18.46 ± 2.7 |
R-( + )-Lansoprazole | 100 | 75.49 ± 2.84 | 84.01 ± 0.77 | 75.86 ± 0.34 |
Ilaprazole(IY 81149) | 100 | 38.9 ± 26.64 | 54.1 ± 22.95 | 30.95 ± 3.71 |
Pantoprazole Sodium | 100 | 30.73 ± 1.42 | 68.03 ± 1.03 | 46.82 ± 1.01 |
pantoprazole sulfide | 100 | 22.91 ± 3.2 | 63.9 ± 4.9 | 18.29 ± 2.19 |
Abeprazole Sulfide | 100 | 28.24 ± 1.07 | 53.33 ± 2.58 | 17.28 ± 4.05 |
Azilsartan | 100 | 0 ± 0 | 6.4 ± 0.77 | 30.28 ± 2.7 |
Telmisartan | 100 | 0 ± 0 | 47.4 ± 4.38 | 42.09 ± 1.69 |
Candesartan cilexetil | 100 | 4.44 ± 2.13 | 81.95 ± 0.52 | 11.37 ± 0.34 |
Dabigatran etexilate | 100 | 5.63 ± 4.07 | 0 ± 0 | 12.52 ± 2.19 |
Pimobendan | 100 | 18.24 ± 4.07 | 2.59 ± 7.47 | 13.46 ± 0.47 |
Astemizole | 100 | 100 ± 0 | 100 ± 0 | 40.17 ± 0 |
Parbendazole | 100 | 71.12 ± 17.9 | 45.92 ± 2.99 | 17.52 ± 5.62 |
Thiabendazole | 100 | 73.97 ± 11.8 | 66.24 ± 5.08 | 36.27 ± 3.44 |
Carbendazim | 100 | 26.78 ± 7.73 | 24.1 ± 26.29 | 14.4 ± 4.22 |
Oxfendazole | 100 | 100 ± 0 | 100 ± 0 | 43.07 ± 0.85 |
Theophylline | 100 | 14.57 ± 1.96 | 23.32 ± 0.67 | 17.46 ± 3.42 |
Imidurea | 100 | 97.31 ± 0.19 | 98.04 ± 0 | 14.07 ± 5.66 |
Imiquimod | 100 | 4.86 ± 0.44 | 49.06 ± 5.27 | 8.43 ± 7.44 |
Daclatasvir | 100 | 13.81 ± 3.36 | 41.58 ± 2.63 | 37.88 ± 1.65 |
Atipamezole hydrochloride | 100 | 92.1 ± 0.29 | 96.52 ± 0.95 | 0 ± 0 |
Albendazole S-oxide | 100 | 0 ± 0 | 8.6 ± 3.69 | 0 ± 0 |
Benzoylmetronildazole | 100 | 37.62 ± 3.15 | 20.72 ± 1.05 | 0 ± 0 |
(+)-Pilocarpine hydrochloride | 100 | 5.02 ± 3.86 | 12.55 ± 1.84 | 0 ± 0 |
Triclabendazole | 100 | 100 ± 0 | 100 ± 0 | 20.86 ± 0.27 |
Metronidazole | 100 | 1.86 ± 11.14 | 21.97 ± 2.02 | 76.27 ± 9.58 |
Ornidazole | 100 | 11.65 ± 15.94 | 13.9 ± 3.36 | 93.91 ± 1.52 |
Tinidazole | 100 | 78.68 ± 1.34 | 21.3 ± 0.67 | 96.5 ± 0.15 |
Ronidazole | 100 | 77.34 ± 1.34 | 15.92 ± 0 | 97.41 ± 0 |
4,5-Dichloro-2-octyl-isothiazolone | 100 | 100 ± 0 | 100 ± 0 | 100 ± 0 |
2-Octyl-2H-isothiazol-3-one | 100 | 100 ± 0 | 100 ± 0 | 100 ± 0 |
Methylisothiazolinone | 100 | 55.00 ± 2.00 | 99.14 ± 0.08 | 98.54 ± 0.78 |
1,2-Benzisothiazol-3(2H)-one | 100 | 100 ± 0 | 100 ± 0 | 100 ± 0 |
2-Methyl-1,2-benzothiazol-3(2H)-one | 100 | 100 ± 0 | 100 ± 0 | 100 ± 0 |
6-Fluoro-1,2-benzoisothiazol-3(2H)-one | 100 | 100 ± 0 | 100 ± 0 | 100 ± 0 |
Thiazol-3-one | 100 | 100 ± 0 | 100 ± 0 | 99.23 ± 0.19 |
5-chloro-3-hydroxyisothiazole | 100 | 100 ± 0 | 100 ± 0 | 100 ± 0 |
5-Chloro-2-Methylisothiazol-3(2H)-one | 100 | 100 ± 0 | 100 ± 0 | 100 ± 0 |
3-(1-Piperazinyl)-1,2-benzisothiazole | 100 | 65.1 ± 9.69 | 94.17 ± 2.91 | 68.22 ± 0.58 |
6-Ethoxy-2-benzothiazolesulfonamide | 100 | 66.91 ± 12.98 | 31.54 ± 3.2 | 74.97 ± 3.82 |
2-(4-chloro-phenyl)-thiazolidine-4-carboxylic acid | 100 | 20.45 ± 0 | 24.16 ± 2.19 | 33.11 ± 3.7 |
Ethyl 2-(2-aminothiazol-4-yl)glyoxylate | 100 | 0 ± 0 | 52.33 ± 0.18 | 0 ± 0 |
Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate | 100 | 100 ± 0 | 79.27 ± 1.95 | 52.92 ± 2.92 |
1,3-Thiazol-2-amine | 100 | 1.11 ± 0.9 | 26.28 ± 0.36 | 11.58 ± 4.39 |
Thiabendazole | 100 | 73.97 ± 11.8 | 66.24 ± 5.08 | 36.27 ± 3.44 |
Ethyl 2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate | 100 | 28.94 ± 0.77 | 33.33 ± 4.48 | 6.6 ± 7.46 |
Acotiamide hydrochloride trihydrate | 100 | 0 ± 0 | 1.64 ± 0.35 | 0 ± 0 |
Febuxostat | 100 | 61.41 ± 13.53 | 22.1 ± 2.84 | 24.8 ± 4.03 |
isavuconazole | 100 | 100 ± 0 | 55.89 ± 2.58 | 86.47 ± 5.15 |
Riluzole | 100 | 98.44 ± 0.45 | 62.52 ± 0.17 | 59.5 ± 2.45 |
