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Halobacin, a herbicidal acyloin derivative from a marine bacterium of the genus Halobacillus

The Journal of Antibiotics volume 78, pages 569–572 (2025)Cite this article

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Abstract

Halobacin (1), a new glycosylated acyloin derivative, was isolated from the fermentation broth of a coral-associated bacterium Halobacillus sp. DUNA-S15. The structure of 1 was determined based on NMR and MS analyses and the absolute configuration of the sugar moiety was determined by diastereomeric HPLC separation using chiral derivatization. Compound 1 was inactive in antimicrobial and cytotoxicity assays but suppressed the root growth of germinated seeds of lettuce and barnyard millet to ca 30% at 1 µg ml−1 and ca 70% at 10 µg ml−1 compared to the nontreated seeds.

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Authors and Affiliations

  1. Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University 5180 Kurokawa, Imizu, Toyama, Japan

    Md. Mehebub Al Raji, Desy Wulan Triningsih & Yasuhiro Igarashi

  2. Department of Marine Science, Faculty of Fisheries and Marine Science, Diponegoro University, Tembalang Campus, St. Prof. Soedarto SH, Semarang, Central Java, Indonesia

    Agus Trianto

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  1. Md. Mehebub Al Raji
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  2. Desy Wulan Triningsih
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  4. Yasuhiro Igarashi
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Correspondence to Yasuhiro Igarashi.

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Raji, M.M.A., Triningsih, D.W., Trianto, A. et al. Halobacin, a herbicidal acyloin derivative from a marine bacterium of the genus Halobacillus. J Antibiot 78, 569–572 (2025). https://doi.org/10.1038/s41429-025-00842-7

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