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A new aurodox-family compound from Streptomyces sp. HKIB0009: structure and antibacterial activity

The Journal of Antibiotics (2026)Cite this article

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Abstract

A new aurodox-family compound named 2-methyl-10-hydroxy-A83016F (1) and the known aurodox (2) were isolated from the Streptomyces sp. HKIB0009; their structures were determined through comprehensive analysis of NMR and HRMS data. The antibacterial activities of these compounds against Escherichia coli, Bacillus subtilis, and Staphylococcus aureus were evaluated using the broth microdilution method. The results showed that compound 1 exhibited weak antibacterial activity.

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Acknowledgements

This work was financially supported by the The Xingdian Talent Support Program Project (No. 20220774), National Natural Science Foundation of China (22177050), and Yunnan Applied Basic Research Project (202301AT070323).

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Authors and Affiliations

  1. School of Pharmaceutical Sciences and Yunnan Provincial Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China

    Xingtao Li & Lijun Chen

  2. State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China

    Xingtao Li, Yuxin Sun, Mimi Tian, Linfang Tang, Yuan Chen, Zikang Zhao & Mingming Cao

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  1. Xingtao Li
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Correspondence to Mingming Cao or Lijun Chen.

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Li, X., Sun, Y., Tian, M. et al. A new aurodox-family compound from Streptomyces sp. HKIB0009: structure and antibacterial activity. J Antibiot (2026). https://doi.org/10.1038/s41429-026-00915-1

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