Fig. 2: Challenges in iPSC-based complex disease modelling.
From: Bridging population and cell: modelling complex diseases with human induced pluripotent stem cells
Modelling complex diseases presents several unique challenges, including capturing subtle to moderate cellular effects, modelling environmental influences, and capturing the entire range of associated genetic variants. Various approaches are under development to meet the requirements for addressing these challenges, such as large-scale iPSC derivation, techniques to capture environmental factors, and iPSC biobanks to include more genetic diversity in iPSC models. iPSC induced pluripotent stem cell. Created with BioRender.
