We read with interest the comment by Cheong et al. [1].

As the comment mentioned, in our study, the diurnal variations was an insurmountable confounding factor to the thickness of choroid and other parts of uvea. As we know, APAC attack usually happened at night, which was speculated be associated with dilating pupil as a result of dim lighting [2]. The attacks in our study were almost in the same situation. The examinations performing at the same timepoint was the most simple and effective way to reduce the confounding effect. Meanwhile, the previous studies about the diurnal variations of choroidal thickness (CT) found that the maximum at 0300 hours, and the minimum at 1800 hours, which meant the CT gradually expand after sunset until midnight [3]. We speculate the trend of choroid expanding might play a role in the angle closure.

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