Previous studies have identified the potential role of temperature and barometric pressure in contributing to a flare of inflammatory symptoms in susceptible rheumotological patients, but this association is controversial and not definitive [1, 2]. Joint inflammation is due in part to the pro-inflammatory role of matrix metalloproteinases (MMPs); enzymes which also have a destructive role towards the corneal extracellular matrix [3]. We wanted to perform a 10-year review of corneal perforations requiring cyanoacrylate gluing in theatre at our university tertiary referral centre to assess for any seasonal association [4].

Patients who underwent emergency gluing procedures in theatre for corneal perforation at Gartnavel General Hospital, Glasgow between 2008 and 2017 were identified from theatre logbooks and their electronic records retrospectively analysed. Audit data included patient demographics, date of perforation, ocular co-morbidities and any associated systemic conditions.

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