We read the article by Zeng et al. who evaluated the use of intravitreal conbercept for treatment of macular oedema, with great interest [1]. Despite reports of significant improvement in vision resulting from the use of monotherapy anti-VEGF agents in patients with macular oedema, it is deemed relatively short term, with evidence of rebound macular oedema following discontinuation of treatment, it is therefore important to consider utilising combination therapy.

In a pilot study of 12 eyes in the LEAVO study, we recorded venous and arterial calibre change to month 24 and investigated associations with the number of injections. This study included fundus images from 12 patients. Using colour fundus photographs of the 12 eyes from the baseline, months 12 and 24, retinal vascular calibre was recorded.

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