With great interest, we read the article by Pose-Bazarra et al published in 2021 in Eye (Lond). The authors performed a meta-analysis to compare the effectiveness and safety of different surgical and laser techniques in people with pseudoexfoliation glaucoma [1]. At the outset, we would like to congratulate the authors for writing an informative article with novelty. While we read the article with pleasure, it must be noted that this study raises some thought-provoking issues. Therefore, we wish to have the opportunity to comment respectfully on this article.

In the past few years, we have seen a substantial increase in the quantity of meta-analyses. The majority, however, have minor or major mistakes that are avoidable by careful adherence to proper methodology. We have to be aware that nowadays clinical practice mostly relies on meta-analyses and guidelines. Thus, they have to be of the highest quality. Only then we can draw the right conclusions. Overall, Pose-Bazarra et al analyzed a valuable issue, but the results of this meta-analysis should be interpreted with caution due to the limitations mentioned above.

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