Fig. 3: EGFP DNA levels in peripheral tissues following IN and IV AAV delivery. | Gene Therapy

Fig. 3: EGFP DNA levels in peripheral tissues following IN and IV AAV delivery.

From: Intranasal versus intravenous AAV delivery: A comparative analysis of brain-targeting efficiency and peripheral exposure in mice

Fig. 3

Copy numbers were quantified in the nasal tissue, lung, heart, liver, stomach, intestine, kidney, and spleen of Swiss (top), BALB/c (middle), and C57BL/6 J (bottom) mice. DNA levels are given as a ratio of EGFP copies to 1000 mouse beta-actin (mActb) gene copies. Data are presented as mean ± SEM (N = 5 mice per group). Nonparametric multiple t-tests were used to analyze this data, and the Mann-Whitney test was used to compare ranks between each group (*p < 0.05, **p < 0.01).

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