Fig. 4: Brain-to-peripheral transduction ratios following IN and IV AAV delivery. | Gene Therapy

Fig. 4: Brain-to-peripheral transduction ratios following IN and IV AAV delivery.

From: Intranasal versus intravenous AAV delivery: A comparative analysis of brain-targeting efficiency and peripheral exposure in mice

Fig. 4

Ratios of mean EGFP DNA levels in the brain were calculated relative to the nasal tissue A, lung B, heart C, liver D, stomach E, intestine F, kidney G, and spleen H. Data from all tested mouse strains were pooled for each plot. The grand mean of the pooled data is shown in each plot, and statistical comparisons between the ranks of pooled IN and IV data were conducted using a two-tailed Mann-Whitney test (ns: not significant, **p < 0.01, ***p < 0.001, and ****p < 0.0001).

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