Fig. 2: Fundus longitudinal in vivo imaging of GFP expression revealed widespread viral transduction in the retina. | Gene Therapy

Fig. 2: Fundus longitudinal in vivo imaging of GFP expression revealed widespread viral transduction in the retina.

From: First pilot study of intravenous rAAV-PAX6 gene therapy increases retinal-ganglion-cell-layer thickness and Notch1 transcription in a mouse model of aniridia

Fig. 2: Fundus longitudinal in vivo imaging of GFP expression revealed widespread viral transduction in the retina.

Fundus retinal images of mice injected at P21 with vehicle control, vehicle control coinjected with smCBA-EmGFP, smCBA-FLAG/PAX6 coinjected with smCBA-EmGFP, or Ple331-FLAG/PAX6 coinjected with smCBA-EmGFP. Retinal imaging of wild-type mice was performed at 1, 3, and 5 months post-injection. Brightfield (BF) and GFP epifluorescence images are shown of a mouse that received A–C vehicle control injection, D–F vehicle control coinjected with smCBA-EmGFP, G–I smCBA-3xFLAG/PAX6 coinjected with smCBA-EmGFP, and J–L Ple331-3xFLAG/PAX6 coinjected with smCBA-EmGFP. The numbers above the panels denote the animal IDs.

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