Fig. 6: At 5 months, the eyes of smCBA-FLAG/PAX6-treated Sey mice had significantly thicker ganglion cell layers. | Gene Therapy

Fig. 6: At 5 months, the eyes of smCBA-FLAG/PAX6-treated Sey mice had significantly thicker ganglion cell layers.

From: First pilot study of intravenous rAAV-PAX6 gene therapy increases retinal-ganglion-cell-layer thickness and Notch1 transcription in a mouse model of aniridia

Fig. 6: At 5 months, the eyes of smCBA-FLAG/PAX6-treated Sey mice had significantly thicker ganglion cell layers.

Immunofluorescence images were examined for Wt and Sey mice that received vehicle control, smCBA-FLAG/PAX6, or Ple331-FLAG/PAX6. The ganglion cell layer thickness was quantified at A 1 month post-injection and B 5 months post-injection. The data shown are the mean ± SEM, with each dot indicating a single retina analysed from each mouse. Statistical significance was determined using ANOVA and, if significant, a post hoc Tukey’s comparison test. A p value < 0.05 was considered to indicate statistical significance. *p ≤ 0.05; **p ≤ 0.01.

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