Fig. 3: Alteration of m6A modification is involved in inflammatory response in Alzheimer’s disease pathogenesis. | Genes & Immunity

Fig. 3: Alteration of m6A modification is involved in inflammatory response in Alzheimer’s disease pathogenesis.

From: N6-methyladenosine RNA modification regulates microglial phagocytosis in the APP/PS1 mouse model of Alzheimer’s disease

Fig. 3

A Reactome enrichment analysis of high-confidence, m6A-modified transcripts in the mouse hippocampus (p < 0.05, fold-change < 0.667 or <1.5). B Reactome enrichment analysis of m6A-modified transcripts by cell type (p < 0.05, fold-change < 0.667 or >1.5). C Network of the top 20 Gene Ontology terms and KEGG pathways focusing on the adaptive immune system (p < 0.05, fold-change < 0.667 or >1.5). D Heatmap of enriched KEGG pathways and Gene Ontology terms in microglial clusters. We used Fisher’s exact test for peak calling (p < 0.05, fold-change < 0.667 or >1.5).

Back to article page