Fig. 4: Lung tissues and AT2 senescence signatures in Calca-/- rats.
From: αCGRP deficiency aggravates pulmonary fibrosis by promoting senescence in alveolar type 2 cells
A Senescence gene set scores were elevated in whole lung tissues of Calca-/- rats compared to WT group. B Senescence gene set scores were elevated in AT2 cells of Calca-/- rats compared to WT group. C KEGG analysis indicated upregulation of lipid metabolism (e.g., linoleic acid metabolism (rno00591), α-linoleic acid metabolism (rno00592), and arachidonic acid metabolism (rno00590), fat digestion and absorption (rno04975), and Th1/Th2 cell differentiation (rno04658) in Calca-/- rats; and downregulation of HIF-1 signaling (rno04066), FoxO signaling (rno04068), and cell cycle (rno04110) pathways in Calca-/- rats. D GO analysis showed increased negative regulation of cell fate commitment (GO: 0010454), fatty acid metabolism (GO: 0045923), stem cell proliferation (GO: 0072089), replicative senescence (GO: 0090399), and T-helper 2 cell cytokine production (GO: 0035745) in Calca-/- rats; oxygen transport (GO: 0015671) were downregulated in Calca-/- rats.
