Fig. 4: Functional annotation of SNPs with selection signal for the different Gene Ontology (GO) categories with potential functional effects of SNP variants based on SNPEff annotation.

The strength of putative functional effects are: Low, is a synonymous variant unlikely to change protein behavior. Moderate, a missense (nonsynonymous) variation or a frame deletion that might change protein effectiveness. High, a stop or frameshift variant, probably causing protein truncation, loss of function or triggering nonsense mediated decay. Modifier, variants affecting non-coding genes, where predictions are difficult or there is no evidence of impact.