Fig. 2: The microinjection workflow, guideRNA locations, and scarlet knockout mutant phenotype.

A The microinjection workflow for CRISPR-Cas9/Cas12 RNP. B The schematic locations for the guide RNA targets for Cas9 and Cas12 gene editing. C The clear-eye phenotype (red arrow) caused by the knock-out of scarlet gene. D Wildtype animal.