Fig. 1: Chromosome-scale assembly and 3D genome architecture of A. latifasciata including the B chromosome.
From: Genome assembly of Astatotilapia latifasciata uncovers B chromosome–linked chromatin reorganization
a Hi-C contact matrix (500 kb bins) showing chromatin interactions within and between chromosomes of A. latifasciata, including chromosomes 1–22 and the assembled “B_superscaffold” representing the B chromosome. Strong intrachromosomal interactions are evident along the diagonal, particularly between euchromatic arms of A chromosomes. Color intensity reflects the frequency of contact between pairs of 100-kb loci. White rows and columns represent bins with no valid interaction data. A magnified view (250 kb resolution) comparing the chromatin architecture of LG8 (Chr 1), LG3 (Chr 2), and Chr B is shown on the right. b Chrom3D structural model of the diploid genome (including the B chromosome). Each chromosome occupies a distinct territory within the nucleus (represented by different colors), with chromosomes modeled as continuous chains of beads, each bead corresponding to a predicted topologically associating domain (TAD). A separate 3D view highlights LG8, LG3, and Chr B in blue, green, and red, respectively.
