Fig. 4

RCS for the baseline prescriptions of β-blockers. RCSs show the baseline prescription of β-blockers after adjusting for age, sex, BMI category, systolic blood pressure, diabetes mellitus, log(UACR), and atrial fibrillation (a) and stratified by the presence of any CVD history—those with any CVD history (b) and those without CVD history (c). RCSs with 95% confidence intervals were truncated at the 1st and 99th percentiles in the CRIC Study and at the 0th and 97th percentiles in the CKD-JAC Study (a); at the 1st and 97th percentiles in the CRIC Study and at the 0th and 96th percentiles in the CKD-JAC Study (b); and at the 1st and 99th percentiles in the CRIC Study and at the 0th and 98th percentiles in the CKD-JAC Study (c). The interaction represents eGFR × cohorts (CKD-JAC vs. CRIC). RCS restricted cubic spline, CVD cardiovascular disease, CHF congestive heart failure, UACR urinary albumin:creatinine ratio