Fig. 2
From: A novel rat model of pulmonary hypertension induced by mono treatment with SU5416
Effects of SU5416 on pulmonary vascular medial wall thickness in rats. a (a, b, and c) Lung tissues from the control rats, the SU5416-treated rats, and the SuHx rats were stained with hematoxylin and eosin, which showed small PA with an OD of 50–100 μm. a (d, e, and f) Images showing the lung tissues from the control group, the SU5416 group, and the SuHx group representing small PA with an OD of 50–100 μm (red: α-SMA; green: vWF; blue: DAPI). b (a and b) Ratios of vessel wall thickness and vessel wall area in the small PA of each group with an OD of 50–100 μm. Representative pictures of one of five rats from the control group, the SU5416 group, and the SuHx group are shown. A total of 78 arteries in the SU5416 group, 80 in the SuHx group, and 50 in the control group were analyzed. (mean ± SE, *P < 0.05, **P < 0.01. n = 5–7)
