Fig. 1
From: Maternal high-fat diet increases vascular contractility in adult offspring in a sex-dependent manner
Effect of maternal HFD on phenylephrine (PE) and angiotensin II (Ang II)-mediated contractions of aortas in adult male and female offspring. PE (a, b n = 5/group)- or Ang II (c, d n = 6/group)-induced contractions in the absence or presence of ʟ-NNA (100 µM, 20 min) were determined in aortas of adult male (left panel) and female (right panel) offspring that had been exposed in utero to a standard laboratory chow diet or HFD. Con control, HFD high-fat diet. The pD2 values and the maximal response (Emax) are presented in Table 1. Values are the means ± SEM. Data were analyzed by two-way ANOVA. *P < 0.05, HFD vs. Con; #P < 0.05, +ʟ-NNA vs. −ʟ-NNA
