Table 1 Effect of maternal HFD on phenylephrine (PE) or angiotensin II-induced contractions of aorta in male and female adult offspring in the absence or presence of ʟ-NNA
From: Maternal high-fat diet increases vascular contractility in adult offspring in a sex-dependent manner
Treatment | Con | HFD | ||
|---|---|---|---|---|
pD2 | Emax | pD2 | Emax | |
Male | ||||
−ʟ-NNA (PE) | 7.2 ± 0.1 | 130.7 ± 6.8 | 8.0 ± 0.1* | 243.4 ± 10.8* |
+ʟ-NNA (PE) | 8.2 ± 0.1# | 249.8 ± 8.2# | 8.1 ± 0.1 | 269.5 ± 6.8 |
−ʟ-NNA (Ang II) | 7.7 ± 0.2 | 33.4 ± 2.3 | 7.8 ± 0.1 | 70.9 ± 2.0* |
+ʟ-NNA (Ang II) | 7.9 ± 0.1 | 57.3 ± 2.2# | 8.3 ± 0.1*# | 87.8 ± 2.3*# |
Female | ||||
−ʟ-NNA (PE) | 8.3 ± 0.1 | 199.9 ± 7.0 | 8.2 ± 0.1 | 198.4 ± 4.9 |
+ʟ-NNA (PE) | 8.4 ± 0.1 | 264.0 ± 7.0# | 8.2 ± 0.1 | 286.4 ± 10.8# |
−ʟ-NNA (Ang II) | 8.1 ± 0.1 | 39.8 ± 1.2 | 8.1 ± 0.1 | 41.0 ± 1.3 |
+ʟ-NNA (Ang II) | 7.9 ± 0.1 | 77.3 ± 1.6# | 7.9 ± 0.1 | 73.1 ± 2.2# |
