Table 4 Summary of studies regarding relationship between serum uric acid level and development of CKD
Mean age | Follow-up duration | Number of study subjects | Analysis by sex | Mean UA | Anti-hyperuricemic drugs | Decline in renal function | Ref | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Authors | Year | Country | Study design | (years) | (years) | (mg/dl) | Baseline Use | Adjustment | ||||||||
All (M/F) | All | M | F | M/F | (%) | Baseline | Follow-up | High UA | Low UA | |||||||
Wakasugi, et al. | 2015 | Japan | Cross-sectional | 64 (64/64) | 0 | 227,645 | 90,710 | 136,935 | + | 6.0/4.7 | ? | − | + | + (M) | [15] | |
Zhu, et al. | 2014 | Meta-analysis (15 cohorts) | ? | + (<60 years) | [4] | |||||||||||
Iseki, et al. | 2004 | Japan | Cohort | 52 | 7 | 48,177 | 22,949 | 25,228 | + | 6.4/4.8 | ? | − | + | [5] | ||
Obermayr, et al. | 2008 | Austria | Cohort | 43 | 7 | 21,475 | 12,399 | 9,076 | + | 5.9/4.2 | ? | − | + | [6] | ||
Bellomo, et al. | 2010 | Italy | Cohort | 43 (44/41) | 5 | 900 | 747 | 153 | + | 5.6/4.2 | ? | − | + | [7] | ||
Wang, et al. | 2011 | Taiwan | Cohort | 40 | 3.5 | 94,422 | 47,588 | 46,834 | + | 6.9/5.1 | 1.0 | + | − | + | [12] | |
Kamei, et al. | 2014 | Japan | Cohort | 63 | 2 | 165,847 | 66,289 | 99,558 | − | ? | ? | − | − | + | [8] | |
Akasaka, et al. | 2014 | Japan | Cohort (1) | 41 (41/40) | 6 | 3,446 | 2,328 | 1,118 | + | 6.0/4.2 | 0 | None | − | + | [14] | |
Akasaka, et al. | 2014 | Japan | Cohort (2) | 62 (63/61) | 6 | 404 | 159 | 245 | + | 5.8/4.5 | 0 | None | − | + | [14] | |
Kanda, et al. | 2015 | Japan | Cohort | 39 (40/38) | 3–9 | 4,188 | 3,148 | 1,040 | + | 5.8/4.1 | ? | − | + | + (M) | [9] | |
Takae et al. | 2016 | Japan | Cohort | 59 | 5 | 2,059 | 851 | 1,208 | − | ? | 1.3 | + | − | + | [13] | |
Matsukuma, et al. | 2017 | Japan | Cohort (IgAN) | 35 (32/33) | 5.1 | 1,218 | 548 | 670 | + | 6.7/5.1 | 2.3 | + | − | + | + (F) | [11] |
Mun, et al. | 2018 | Korea | Cohort | 60 (61/60) | 3.9 | 5,577 | 2,133 | 3,444 | + | ? | ? | − | − | + | + (M) | [10] |
Mori, et al. | 2020 | Japan | Cohort | 45 (45/44) | 10 | 6,779 | 4,454 | 2,325 | + | 6.1/4.3 | 0 | None | + M/F 8.4%/0.3% | + | + (F) | This study |
