Table 1 Participant characteristics stratified by sex

From: Effect of age stratification on the association between carotid intima-media thickness and cognitive impairment in Chinese hypertensive patients: new insight from the secondary analysis of the China Stroke Primary Prevention Trial (CSPPT)

Characteristics

Total

Male

Female

P value

N

14,322

5854

8468

 

Age, years

64.2 ± 7.4

65.5 ± 7.4

63.4 ± 7.2

<0.001

BMI, kg/m2

25.0 ± 3.8

24.2 ± 3.6

25.6 ± 3.9

<0.001

SBP, mmHg

135.4 ± 17.4

132.9 ± 17.0

137.1 ± 17.5

<0.001

DBP, mmHg

82.0 ± 10.9

82.2 ± 11.4

81.8 ± 10.5

0.045

Laboratory examination

 Total cholesterol, mmol/L

5.3 ± 1.1

5.1 ± 1.0

5.5 ± 1.1

<0.001

 Triglyceride, mmol/L

1.8 ± 1.4

1.6 ± 1.4

1.9 ± 1.5

<0.001

 HDL-C, mmol/L

1.3 ± 0.3

1.3 ± 0.3

1.3 ± 0.3

0.015

 FBG, mmol/L

6.3 ± 2.0

6.2 ± 2.0

6.3 ± 2.0

0.183

 tHcy, μmol/L

13.5 ± 6.7

15.3 ± 8.4

12.2 ± 4.9

<0.001

 eGFR, ml/min/1.73m2

88.8 ± 15.0

87.2 ± 15.4

89.9 ± 14.6

<0.001

CIMT, mm

0.74 ± 0.12

0.76 ± 0.12

0.73 ± 0.11

<0.001

MMSE

23.5 ± 4.8

26.0 ± 4.2

21.8 ± 4.5

<0.001

Education, N(%)

   

<0.001

 Illiteracy

8417 (58.8)

1889 (32.3)

6528 (77.1)

 Primary school

3226 (22.5)

1918 (32.8)

1308 (15.4)

 Secondary school and above

2679 (18.7)

2047 (35.0)

632 (7.5)

MTHFR C677T genotype, N(%)

   

0.524

 CC

3897 (27.2)

1621 (27.7)

2276 (26.9)

 CT

6985 (48.8)

2845 (48.6)

4140 (48.9)

 TT

3440 (24.0)

1388 (23.7)

2052 (24.2)

Smoking status, N(%)

   

<0.001

 Never

9579 (67.0)

1469 (25.2)

8110 (95.9)

 Former

1590 (11.1)

1456 (24.9)

134 (1.6)

 Current

3127 (21.9)

2913 (49.9)

214 (2.5)

Alchol consumption, N(%)

   

<0.001

 Never

9625 (69.8)

1771 (32.9)

7854 (93.5)

 Former

936 (6.8)

781 (14.5)

155 (1.8)

 Current

3220 (23.4)

2830 (52.6)

390 (4.6)

Research center, N(%)

   

<0.001

 Anqing

3067 (21.4)

1431 (24.4)

1636 (19.3)

 Lianyungang

11255 (78.6)

4423 (75.6)

6832 (80.7)

Treatment group, N(%)

   

0.799

 Enalapril

7150 (49.9)

2930 (50.1)

4220 (49.8)

 Enalapril-folic acid

7172 (50.1)

2924 (49.9)

4248 (50.2)

  1. Values are n (%) or mean ± SD
  2. BMI Body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, HDL-C high-density lipid cholesterol, FBG Fasting blood glucose, tHcy total Homocysteine, eGFR estimated glomerular filtration rate, CIMT carotid intima-media thickness, MMSE Mini- Mental State Examination; MTHFR methylenetetrahydrofolate reductase
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