Table 2 Association of CIMT and MMSE for males and females

From: Effect of age stratification on the association between carotid intima-media thickness and cognitive impairment in Chinese hypertensive patients: new insight from the secondary analysis of the China Stroke Primary Prevention Trial (CSPPT)

Exposure

N

MMSE

Crude model

P value

Adjusted model

P value

Mean ± SD

β (95%CI)

β (95%CI)

Male

CIMT, mm

5854

26.0 ± 4.2

−5.66 (−6.55, −4.76)

<0.001

−1.26 (−2.05, −0.47)

0.002

Quartile

 Q1: <0.68

1427

26.9 ± 3.7

Ref

 

Ref

 

 Q2: 0.68-<0.75

1500

26.3 ± 4.0

−0.60 (−0.89, −0.30)

<0.001

−0.22 (−0.47, 0.03)

0.082

 Q3: 0.75-<0.83

1454

25.8 ± 4.3

−1.10 (−1.40, −0.80)

<0.001

−0.31 (−0.56, −0.05)

0.020

 Q4: ≥0.83

1473

25.1 ± 4.4

−1.73 (−2.03, −1.43)

<0.001

−0.46 (−0.72, −0.19)

0.001

P for trend

   

<0.001

 

0.001

Female

CIMT, mm

8468

21.8 ± 4.5

−4.51 (−5.41, −3.60)

<0.001

−0.66 (−1.49, 0.17)

0.120

Quartile

 Q1: <0.65

2063

22.5 ± 4.5

Ref

 

Ref

 

 Q2: 0.65-<0.72

2120

22.0 ± 4.4

−0.51 (−0.78, −0.23)

<0.001

−0.10 (−0.34, 0.13)

0.400

 Q3: 0.72-<0.78

2144

21.7 ± 4.4

−0.82 (−1.09, −0.55)

<0.001

−0.10 (−0.34, 0.14)

0.408

 Q4: ≥0.78

2141

21.2 ± 4.4

−1.30 (−1.57, −1.03)

<0.001

−0.13 (−0.38, 0.11)

0.286

P for trend

   

<0.001

 

0.317

  1. *Adjusted for: age, education, body mass index, systolic and diastolic blood pressure, methylenetetrahydrofolate reductase C677T genotype, smoking status, alcohol consumption, total cholesterol, triglyceride, high density lipoprotein cholesterol, fasting blood glucose, estimated glomerular filtration rate, total homocysteine, treatment group and research center
  2. CI confidence interval, MMSE Mini- Mental State Examination, CIMT carotid intima-media thickness
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