Table 3 The association of CIMT and MMSE in males and females stratified by age of <60 years or ≥60 years

From: Effect of age stratification on the association between carotid intima-media thickness and cognitive impairment in Chinese hypertensive patients: new insight from the secondary analysis of the China Stroke Primary Prevention Trial (CSPPT)

Exposure

N

MMSE

Crude model

P value

Adjusted model

P value

mean ± SD

β (95%CI)

β (95%CI)

Males

Age <60 years

CIMT, mm

1457

27.7 ± 3.1

−1.22 (−2.71, 0.27)

0.108

−0.63 (−1.97, 0.71)

0.357

Quartile

 Q1: <0.645

364

28.0 ± 2.9

Ref.

 

Ref.

 

 Q2:0.645-<0.708

364

27.6 ± 3.2

−0.41 (−0.86, 0.03)

0.069

−0.35 (−0.74, 0.04)

0.079

 Q3:0.708-<0.775

361

27.7 ± 3.1

−0.29 (−0.74, 0.15)

0.200

−0.14 (−0.53, 0.25)

0.485

 Q4: ≥0.775

368

27.6 ± 3.0

−0.36 (−0.81, 0.08)

0.108

−0.16 (−0.56, 0.24)

0.426

P for trend

   

0.176

 

0.654

Age ≥60 years

CIMT, mm

4397

25.4 ± 4.3

−4.60 (−5.67, −3.52)

<0.001

−2.29 (−3.23, −1.36)

<0.001

Quartile

 Q1: <0.700

1084

26.2 ± 4.0

Ref.

 

Ref.

 

 Q2:0.700-<0.767

1110

25.6 ± 4.3

−0.63 (−0.99, −0.27)

0.001

−0.47 (−0.77, −0.16)

0.003

 Q3:0.767-<0.845

1086

25.3 ± 4.4

−0.89 (−1.25, −0.53)

<0.001

−0.66 (−0.97, −0.35)

<0.001

 Q4: ≥0.845

1117

24.7 ± 4.5

−1.48 (−1.84, −1.12)

<0.001

−0.79 (−1.11, −0.48)

<0.001

P for trend

   

<0.001

 

<0.001

Females

Age <60 years

CIMT, mm

2900

23.2 ± 4.3

−2.26 (−3.97, −0.54)

0.010

−0.37 (−1.83, 1.10)

0.625

Quartile

 Q1: <0.627

696

23.4 ± 4.4

Ref.

 

Ref.

 

 Q2:0.627-<0.685

743

23.2 ± 4.4

−0.19 (−0.64, 0.25)

0.397

−0.05 (−0.42, 0.33)

0.804

 Q3:0.685-<0.745

736

23.1 ± 4.3

−0.27 (−0.72, 0.18)

0.240

−0.19 (−0.57, 0.19)

0.335

 Q4: ≥0.745

725

23.0 ± 4.1

−0.44 (−0.89, 0.01)

0.053

0.03 (−0.36, 0.41)

0.889

P for trend

   

0.052

 

0.931

Age ≥60 years

CIMT, mm

5568

21.1 ± 4.4

−2.59 (−3.67, −1.52)

<0.001

−1.96 (−2.97, −0.95)

<0.001

Quartile

 Q1: <0.670

1353

21.6 ± 4.4

Ref.

 

Ref.

 

 Q2:0.670-<0.735

1379

21.2 ± 4.4

−0.38 (−0.71, −0.05)

0.023

−0.32 (−0.62, −0.02)

0.037

 Q3:0.735-<0.802

1418

21.1 ± 4.4

−0.44 (−0.77, −0.11)

0.008

−0.37 (−0.67, −0.07)

0.016

 Q4: ≥0.802

1418

20.8 ± 4.4

−0.77 (−1.10, −0.45)

<0.001

−0.56 (−0.87, −0.26)

<0.001

P for trend

   

<0.001

 

<0.001

  1. *Adjusted for: education, body mass index, systolic and diastolic blood pressure, methylenetetrahydrofolate reductase C677T genotype, smoking status, alcohol consumption, total cholesterol, triglyceride, high density lipoprotein cholesterol, fasting blood glucose, total homocysteine, estimated glomerular filtration rate, total homocysteine, treatment group and research center.
  2. CI confidence interval, MMSE Mini-Mental State Examination, CIMT carotid intima-media thickness
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