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Response to: Comment on ‘Risk prediction score and equation for progression of arterial stiffness using Japanese longitudinal health examination data’

Hypertension Research volume 48, pages 2124–2125 (2025)Cite this article

We appreciate the correspondence from Lin et al. [1] expressing their interest in our article that created an equation and prediction score for brachial–ankle pulse wave velocity (baPWV) ≥ 1400 cm/s after 5 years [2]. Their comment highlights the strengths and weaknesses of this study.

We identified factors associated with baPWV ≥ 1400 cm/s after 5 years including age, systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, fasting blood sugar (FBS), triglyceride (TG), estimated glomerular filtration rate (eGFR), habitual drinking, and smoking history in men, and age, body mass index (BMI), SBP, DBP, FBS, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TG, and eGFR in women [2]. As Lin et al. identified, LDL-C and HDL-C did not correlate with baPWV ≥ 1400 cm/s after 5 years in the Japanese cohort. Our previous study also found that baPWV was not significantly correlated with LDL-C (r = 0.078) or HDL-C (r = 0.019) in Japanese men and was only weakly correlated with LDL-C (r = 0.283, p < 0.001) and HDL-C (r = 0.196, p < 0.001) in Japanese women [3]. Therefore, the correlation between baPWV and LDL-C or HDL-C is weak in the Japanese population.

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References

  1. Lin X, Song J, Xie M. Comment on “Risk prediction score and equation for progression of arterial stiffness using Japanese longitudinal health examination data”. Hypertens Res. 2025. https://doi.org/10.1038/s41440-025-02203-1.

  2. Inadome N, Kawasoe S, Miyata M, Kubozono T, Ojima S, Mori R, et al. Risk prediction score and equation for progression of arterial stiffness using Japanese longitudinal health examination data. Hypertens Res (epub ahead of print 2025 Feb; https://doi.org/10.1038/s41440-024-02057-z).

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Authors and Affiliations

  1. Graduate School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

    Naoko Inadome, Masaaki Miyata & Ryuko Mori

  2. Department of Nursing, Faculty of Nursing, International University of Kagoshima, Kagoshima, Japan

    Naoko Inadome

  3. Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

    Shin Kawasoe, Takuro Kubozono, Satoko Ojima & Mitsuru Ohishi

  4. Kagoshima Kouseiren Hospital, Kagoshima, Japan

    Hironori Miyahara & Koichi Tokushige

Authors
  1. Naoko Inadome
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  2. Shin Kawasoe
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  4. Takuro Kubozono
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Correspondence to Masaaki Miyata.

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Inadome, N., Kawasoe, S., Miyata, M. et al. Response to: Comment on ‘Risk prediction score and equation for progression of arterial stiffness using Japanese longitudinal health examination data’. Hypertens Res 48, 2124–2125 (2025). https://doi.org/10.1038/s41440-025-02226-8

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