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Obesity and hypertensive renal arteriosclerosis in CKD

Hypertension Research (2026)Cite this article

Dear Editor,

We commend Okamoto et al. for a valuable analysis of zero‑hour donor biopsies, a setting that offers an unusually clean window into subclinical renal injury [1]. This work advances our understanding of how age, blood pressure, and obesity interact long before chronic kidney disease becomes clinically visible. This study is particularly instructive both for the patterns the authors report and the conceptual shifts these patterns invite.

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References

  1. Okamoto H, Matsukuma Y, Ataka E, Ueki K, Tsuchimoto A, Masutani K, et al. Synergistic effect of obesity on hypertensive renal arteriosclerosis in individuals without chronic kidney disease: a zero-hour biopsy-based cohort study. Hypertens Res. 2026;1–1.https://doi.org/10.1038/s41440-026-02553-4.

  2. Miyaoka Y, Okada T, Tomiyama H, Morikawa A, Rinno S, Kato M, et al. Structural changes in renal arterioles are closely associated with central hemodynamic parameters in patients with renal disease. Hypertens Res. 2021;44:1113–21.

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Authors and Affiliations

  1. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran

    Mohammad Pourhooshmandi

  2. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Ali Hosseini & Ali Abasi

Authors
  1. Mohammad Pourhooshmandi
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  2. Ali Hosseini
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  3. Ali Abasi
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Contributions

Mohammad Pourhooshmandi: Conceptualization, Drafting. Ali Hosseini: Conceptualization, Review and revision. Ali Abasi: Conceptualization, Supervision, Review and revision.

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Correspondence to Ali Abasi.

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The authors declare no competing interests.

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Cite this article

Pourhooshmandi, M., Hosseini, A. & Abasi, A. Obesity and hypertensive renal arteriosclerosis in CKD. Hypertens Res (2026). https://doi.org/10.1038/s41440-026-02613-9

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