Table 3 Median values, (IQR) and [n] of available measurements of biomarkers in men >= 56 years of age separated into three groups with lowest, low, and normal testosterone
From: Association of low testosterone with changes in non-cardiovascular biomarkers in adult men
Hormonal biomarkers | Lowest testosterone [n = 327] | Low testosterone [n = 425] | Normal testosterone [n = 4454] | P-value* |
|---|---|---|---|---|
25-hydroxy-vitamin D (nmol/L) | 41 (31–58) [n = 29] | 50 (43–58) [n = 15] | 55 (40–75) [n = 276] | 0.03 [n = 320] |
Estradiol (pmol/L) | 40 (29–50) [n = 16] | 56 (45–75) [n = 32] | 90 (66–112) [n = 565] | <0.001 [n = 613] |
Free testosterone (pmol/L) | 59 (20–86) [n = 118] | 130 (110–160) [n = 193] | 290 (230–370) [n = 2370] | <0.001 [n = 2681] |
LH (IU/L) | 2.8 (1.2–9.4) [n = 121] | 3.8 (2.3–8.5) [n = 128] | 4.0 (2.6–6.5) [n = 1346] | 0.04 [n = 1595] |
SHBG (nmol/L) | 33 (21–52) [n = 1] | 29 (20–41) [n = 2] | 39 (29–52) [n = 18] | <0.001 [n = 21] |
Non-hormonal biomarkers | ||||
Age (years) | 68 (62–75) [n = 327] | 66 (61–72) [n = 425] | 65 (60–71) [n = 4454] | <0.001 [n = 5206] |
BAP (U/L) | 78 (67–94) [n = 99] | 81 (65–103) [n = 111] | 75 (62–93) [n = 1411] | 0.11 [n = 1621] |
BMI (kg/m2) | 28 (25–31) [n = 31] | 28 (25–31) [n = 55] | 26 (24–29) [n = 374] | <0.001 [n = 460] |
CK (U/L) | 183 (168–197) [n = 2] | 175 (175–175) [n = 1] | 105 (83–155) [n = 34] | 0.18 [n = 37] |
Creatinine (µmol/L) | 94 (82–113) [n = 212] | 96 (86–112) [n = 276] | 92 (81–107) [n = 2870] | 0.001 [n = 3358] |
Free PSA (µg/L) | 1.7 (1.7–1.7) [n = 327] | 1.6 (1.5–1.6) [n = 425] | 1.3 (0.9–1.7) [n = 4454] | 0.48 [n = 5206] |
HBA1c (mmol/mol) | 40 (37–47) [n = 74] | 40 (37–49) [n = 100] | 40 (37–44) [n = 1138] | 0.27 [n = 1312] |
LDH (U/L) | 221 (184–326) [n = 61] | 210 (186–252) [n = 92] | 199 (173–246) [n = 1159] | 0.008 [n = 1312] |
Myoglobin (µg/L) | — | — | 90 (90–90) [n = 1] | Not applicable |
PSA (µg/L) | 0.94 (0.20–3.23) [n = 68] | 1.10 (0.62–2.10) [n = 115] | 1.40 (0.70–2.80) [n = 1338] | 0.008 [n = 1521] |
Uric acid (mmol/L) | 0.38 (0.33–0.43) [n = 4] | 0.42 (0.37–0.45) [n = 12] | 0.34 (0.29–0.42) [n = 162] | 0.11 [n = 178] |
