Table 2 Invasive treatment for penile enlargement. A comparison between the outcomes from soft tissue filling, grafting and biodegradable scaffolds implantation for penile girthening, resulting from several studies.

From: Male esthetic genital surgery: recommendations and gaps to be filled

 

STUDIES

n

Age (years)

Pre-operatory GIRTH

THERAPY

POST- OPERATORY GIRTH

SATISFACTION

COMPLICATIONS

SOFT TISSUE FILLERS

Kwak et al. 2010

41

42.5

At midshaft 7.48 (SD 0. 35) cm

20.56 ml of HA

+3.92, SD 0.25 cm (1 month)

+3.78, SD 0.26 cm (18 month)

18 months 100% patients satisfied (VAS)

Not reported

Casavantes et al. 2015

203

37

Mid

10.54 (SD 1.49) cm

20 ml

PMMA

Base 13

(SD 1.46) cm

Mid 12.76 (SD 1.41) cm

83%patients satisfied (grade 8–10)

-Nodules (52%)

-Sensitivity decreased (2%)

-Erectile function decreased (1.5%)

GRAFTS

Spyropoulos et al. [82]

5

30

Subcoronal

6.0 (SD 0.4) cm

Autologous Dermal fat graft

Base

+ 2.3, SD 0.25 cm

Subcoronal

+2.6, SD 0.25 cm

7.54 (Post operatory APPSSI)

-Curvature with pain (25%)

-Pain on erection and hypertrophic scar formation (75%)

Alei et al. [86]

60

28.2

Flaccid

8.1 cm

Porcine dermal acellular matrix graft

Flaccid

11.3 cm

Erect

13.2 cm

98% patients satisfied (Post operatory APPSSI)

-Moderate fibrosis with minor retractions (6.21%)

-Suture dehiscent (5.58%)

BIODEGRADABLE SCAFFOLDS

Djordjevic et al. [91]

21

28

Flaccid

11.6

(SD 0.8) cm

PLGA scaffold

+

Fibroblasts

Flaccid

+ 1.1, SD 0.4 cm

Erect

+1.0, SD 0.3

cm

100% patients satisfied (Mark 3–5)

-Partial superficial necrosis (10%)

Zhe Jin et al. 2010

69

33

Flaccid

8.18 (SD 0.83) cm

Erect STUDIES

PLGA scaffold

+

Fibroblasts

Flaccid

+ 3.15, SD 0.42 cm

Erect

+2.47, SD 0.49 cm

94.2% patients satisfied (VAS 3–10)

-Subcutaneous edema (2%)

-Pinpoint erosion at the suture (2%)

  1. N number of patients treated and evaluated on follow up, Age mean age of the cohort patients, APPSSI The Augmantation Phalloplasty Patient Selection and Satisfaction Inventory, VAS Visual Analogue Scale, PMMA polymethyl-methacrylate Microspheres, HA hyaluronic acid, PLGA poly-lactic-co-glycolic acid.