Table 1 Factors that increase or decrease levels of SHBG in women.

From: The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review

Factors that increase sex hormone binding gobulin

Factors that decrease sex hormone binding gobulin

Aging

Obesity

Infectious disease (HIV, Hepatitis C)

Diabetes, insulin resistance

Hyperthyrodism

Hypothyroidism

Hepatocellular dysfunction

Polycystic ovarian syndrome

Elevated estrogen

Hyperprolactinaemia

Medications (thiazolidines, anticonvulsants, oral contraceptives, selective estrogen receptor modulators)

Medications (glucocorticoids, tyrosine kinase, inhibitors, androgens)

Sex hormone binding polymorphisms

Hypercorticism

Extreme weight loss

Acromegaly

 

Nephrotic syndrome

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