Table 2 GRADE summary.
From: A systematic review of non-surgical management in Peyronieʼs disease
Non-surgical treatment | Evidence for improvement? (GRADE level of evidence) | ||||
|---|---|---|---|---|---|
Penile curvature | Plaque size | Pain | IIEF | Penile length | |
Oral | |||||
Vitamin E | Yes (Moderate) | Yes (Moderate) | No (Moderate) | Yes (Moderate) | N/A |
Tamoxifen | No (Very Low) | No (Low) | No (Very Low) | N/A | N/A |
POTABA | Yes (Low) | Yes (Low) | N (Very Low) | N/A | N/A |
PDEi-5 | No (Low) | No (Very Low) | Yes (Low) | Yes (Low) | N/A |
Colchicine | No (Low) | No (Very Low) | No (Very Low) | N/A | N/A |
Carnitine | Yes (Very Low) | Yes (Very Low) | No (Very Low) | No (Low) | N/A |
Co-Enzyme Q10 | Yes (Low) | Yes (Low) | No (Low) | Yes (Low) | N/A |
Intralesional | |||||
Intralesional CCH | Yes (Moderate) | N/A | No (Moderate) | Yes (Low) | Yes (Low) |
Interferon | Yes (Very Low) | Yes (Low) | Yes (Low) | No (Low) | N/A |
Intralesional CCB | No (Low) | Yes (Low) | Yes (Low) | Yes (Low) | N/A |
HA | Yes (Low) | No (Very Low) | N/A | No (Very Low) | N/A |
Intralesional thiocolchicine | Yes (Low) | No (Low) | N/A | No (Low) | N/A |
Topical | |||||
ESWT | Yes (Low) | Yes (Moderate) | Yes (Low) | Yes (Moderate) | No (Low) |
Electromotive | Yes (Moderate) | Yes (Moderate) | Yes (Moderate) | No (Moderate) | No (Moderate) |
Traction device | Yes (Moderate) | N/A | No (Moderate) | No (Moderate) | Yes (Moderate) |
Laser | Yes (Moderate) | No (Moderate) | Yes (Moderate) | Yes (Moderate) | No (Moderate) |
Topical therapy | No (Low) | Yes (Low) | Yes (Low) | N/A | Yes (Low) |
