Fig. 2
From: Two-step synthesis of chiral fused tricyclic scaffolds from phenols via desymmetrization on nickel
Evaluation of Ligands. (R,R)-L*n·HBF4, NaOtBu, Ni(cod)2 (0.01 mmol each), 1a (0.12 mmol), 2a (0.10 mmol), and toluene (1.0 ml) are employed. Isolated yields are given and enantioselectivity was determined by SFC equipped with a chiral stationary phase. aYield and enantioselectivity was measured at 27% conversion in 3 days. b5 ml toluene was employed and reaction was conducted at 60 °C. c10 mol% IPr was used instead of chiral NHC salt and NaOtBu. d20 mol% PCy3 was used instead of chiral NHC salt and NaOtBu
