Fig. 7
From: Negri bodies are viral factories with properties of liquid organelles
A model for the dynamics of RNPs and NBs in RABV infected cells treated (+NCZ) or not (−NCZ) by Nocodazole. 1. and 2. The initial NB is formed around an incoming RNP. 3. RNPs are ejected from NB by a process which is microtubule independent and are transported away from the initial NB along the microtubule network (−NCZ) or remain in the vicinity of the initial NB when the cells are treated by Nocodazole (+NCZ). 4. In untreated cells (–NCZ), the newly formed RNPs can give rise either to new virions upon budding at the cell membrane or to new viral factories which form NBs of intermediate size. In Nocodazole-treated cells (+NCZ), the newly formed viral factories are located in the vicinity and rapidly fuse with the initial NB which then becomes much larger
