Fig. 3
From: Triggerable tough hydrogels for gastric resident dosage forms
Triggerable properties of TTHs. a Plot of compressive stress of the TTH at strain of 80% vs. the incubation time with EDTA and GSH at 37 °C. Error bars show standard deviation (n = 3). b Pictures of the TTH dissolved into viscous solution after 1 h incubation with 80 mM of EDTA and 20 mM of GSH. c Photographs of the initial TTH strip before administration, and the retrieved TTH strips after 1 h residence in the gastric cavity of the control and triggered pigs, respectively. d Endoscopy images of the TTH sheets in the stomach from the control and triggered pigs, respectively. The TTH sheets were labeled with methyl blue. The pigs were treated with 40 mM of EDTA and 20 mM of GSH after delivery of the TTH strips or sheets through the esophagus. Control animals did not receive EDTA/GSH. Scale bar: 1 cm
