Fig. 4
From: Triggerable tough hydrogels for gastric resident dosage forms
Gastric retention and drug release of TTHs in pigs. a Representative X-ray images of a TTH device residing in the gastric cavity of a Yorkshire pig. Scale bar: 10 cm. b Plot of remaining percentage of the intact TTH devices in the pig stomach monitored by X-ray imaging vs. time post administration (the inset represents endoscopic image of the TTH device after 8 days retention in the gastric cavity). Plot of blood-drug concentration as a function of time post administration: c free lumefantrine; d the lumefantrine-loaded TTH device. In the pig experiments, one TTH device per pig was implanted at day 0 through the esophagus. The capsule-like TTH devices with an initial volume of 22 ml (diameter, 2.8 cm; total length, 5 cm) were labeled by radiopaque barium sulfate for the gastric residence evaluation or loaded with lumefantrine for the pharmacokinetic study. Error bars show standard deviation (n = 3-4)
