Fig. 7
From: Ubiquitination of stalled ribosome triggers ribosome-associated quality control
ASCC3, a human homolog of yeast Rqt2 is required for RQC induced by poly(A) sequence. a Rqt1 factors were required for RQC induced by poly-lysine sequences in yeast. b The AAA repeat induces RQC in mammalian cells. c Schematic drawing of alignment of the domain structure of ZNF598/hRqt1 and ASCC3/hRqt2. d ZNF598 and ASCC3 were localized mainly in cytosol. e ZNF598 was co-purified with ASCC3. f ZNF598 is involved in translation repression and the production of RQC substrate by K(AAA)24 sequence. g ASCC3 is a homolog of Rqt2 in mammalian cells
