Table 2 Genome-wide significant associations for each disease part 1

From: Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections

Phenotype

Cytoband

Gene context

Variants

Alleles a

Freq

OR/effect b

(95% CI)

P value

Chickenpox

6p21.33

HLA

rs9266089

G/A

0.85

1.12

(1.1–1.14)

1.00E-10

Shingles

6p21.33

HLA

rs2523591

G/A

0.58

1.14

(1.13–1.16)

1.74E-27

 

9p21.3

IFNA21

rs7047299

A/G

0.56

1.07

(1.06–1.09)

1.67E-08

Cold sores

6p21.33

HLA

rs885950

C/A

0.42

1.08

(1.07–1.09)

7.47E-13

Mononucleosis

6p21.33

HLA

rs2596465

T/C

0.47

1.08

(1.06–1.09)

2.48E-09

Mumps

19q13.33

FUT2

rs516316

C/G

0.48

1.25

(1.24–1.27)

9.63E-72

 

6p22.1

HLA

rs114193679

G/C

0.99

1.72

(1.62–1.84)

2.23E-17

 

14q32.2

C14orf132--[]--BDKRB2

rs11160318

G/A

0.68

1.1

(1.08–1.11)

4.56E-12

 

11q24.2

ST3GAL4

rs3862630

T/C

0.12

1.13

(1.1–1.15)

1.21E-08

Hepatitis A

19q13.2

IFNL4

rs66531907

A/C

0.21

1.23

(1.14–1.33)

5.70E-08

Hepatitis B

6p21.32

HLA

rs9268652

G/A

0.74

1.32

(1.25–1.38)

3.14E-09

Plantar warts

6p21.32

HLA

rs9272050

G/A

0.38

1.19

(1.17–1.21)

9.66E-31

 

1q21.3

CRCT1--[]--LCE3E

rs6692209

T/C

0.62

1.08

(1.06–1.09)

5.25E-09

Positive TB test

6p21.32

HLA

rs2894257

C/G

0.53

1.36

(1.33–1.39)

8.16E-36

Strep throat

6p21.33

HLA

rs1055821

T/G

0.06

0.08

(0.06–0.09)

7.69E-11

 

1p36.23

ERRFI1---[]---SLC45A1

rs35395352

D/I

0.72

0.03

(0.03–0.04)

3.90E-08

Scarlet fever

6p21.32

HLA

rs36205178

C/T

0.81

1.24

(1.21–1.28)

9.49E-14

Pneumonia

6p21.33

HLA

rs3131623

T/A

0.85

1.1

(1.09−1.12)

1.99E-15

Bacterial meningitis

17q21.33

CA10

rs1392935

G/A

0.91

1.78

(1.6−1.99)

1.19E-08

Yeast infections

18q12.1

DSG1

rs200520431

D/I

0.07

0.11

(0.09−0.12)

1.87E-16

 

14q23.1

PRKCH

rs2251260

T/C

0.17

0.05

(0.04−0.06)

3.46E-10

 

14q32.2

[]---C14orf177

rs7161578

T/C

0.39

0.04

(0.03−0.04)

4.04E-08

UTI frequency

8q24.3

JRK-[]-PSCA

rs2976388

G/A

0.56

0.04

(0.04−0.05)

3.27E-10

 

15q15.3

FRMD5

rs146906133

T/C

1.00

0.38

(0.32−0.45)

2.02E-08

Childhood ear Infections

19q13.33

FUT2

rs681343

C/T

0.52

1.11

(1.1–1.12)

3.51E-30

 

22q11.21

TBX1

rs1978060

G/A

0.60

1.09

(1.08–1.1)

1.17E-19

 

10p12.1

RAB18--[]--MKX

rs2808290

C/T

0.51

1.07

(1.07–1.08)

5.09E-16

 

15q26.2

SPATA8---[]---LINC00923

rs7174062

G/A

0.73

1.08

(1.07–1.09)

3.49E-14

 

6p21.32

HLA

rs4329147

T/C

0.83

1.11

(1.09–1.13)

9.55E-12

 

9q34.2

ABO

rs8176643

D/I

0.36

1.06

(1.05–1.07)

3.67E-11

 

2p16.1

EFEMP1

rs1802575

G/C

0.87

1.09

(1.07–1.1)

1.47E-10

 

2p24.1

NT5C1B-RDH14---[]---OSR1

rs5829676

D/I

0.40

1.06

(1.05–1.07)

1.78E-10

 

11q13.3

FGF3---[]--ANO1

rs72931768

G/C

0.88

1.09

(1.07–1.1)

2.63E-09

 

7q11.22

AUTS2

rs35213789

C/T

0.74

1.06

(1.05–1.07)

3.75E-09

 

7q22.3

CDHR3

rs114947103

C/T

0.18

1.07

(1.06–1.08)

5.40E-09

 

8q22.2

NIPAL2--[]--KCNS2

rs13281988

C/G

0.31

1.06

(1.05–1.07)

9.84E-09

 

3p21.31

BSN

rs67035515

I/D

0.18

1.07

(1.05–1.08)

1.56E-08

 

6q26

PLG

rs73015965

G/A

0.01

1.43

(1.34–1.53)

3.78E-08

Myringotomy

22q11.21

TBX1

rs1978060

G/A

0.60

1.17

(1.14–1.2)

3.34E-10

  1. HLA human leukocyte antigen, SNP single-nucleotide polymorphism, TB tuberculosis, UTI urinary tract infection
  2. aThe alleles for each SNP are represented as high-risk allele/low-risk allele
  3. bStrep throat, plantar warts and UTI frequency are quantitative traits, for which we reported the effect size instead of the odds ratio
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