Fig. 1

A modularized map of E2F1 in tumor progression and metastasis. The map contains three E2F1 regulatory compartments: (i) Extra-/intracellular receptor signaling (n = 113); (ii) Post-translational modifications of E2F1 (n = 24); (iii) Regulators of E2F1 transcriptional activity (n = 66). Furthermore, there are seven functional compartments: (i) Cell cycle (n = 145); (ii) Quiescence (n = 29); (iii) DNA repair (n = 33); (iv) Metabolism (n = 11); (v) Apoptosis (n = 89); (vi) Survival (n = 52); (vii) EMT/invasion/angiogenesis (n = 69), where n stands for the number of factors in each compartment. Biomolecules are visualized in standard CellDesigner format (gene: yellow rectangle; protein: light green round cornered box; receptor: light yellow hexagon; ligand: green oval; phenotype: violet hexagon; drug/external stimulus: pink box). For better visualization, in the map transcription and translation are condensed to one reaction directly leading from gene to protein. In red, we represent place holders for protein families (e.g., FGFR for FGFR1-4, FGF for FGF1-23, ITGA, and ITGB for alpha and beta integrins) and unspecified genes responding to a given transcription factor. The microRNA layer is not included in this CellDesigner diagram, but in the Cytoscape network provided as Supplementary Information. The interactive E2F1 interaction map can be accessed at: https://navicell.curie.fr/pages/maps_e2f1.html