Fig. 1
From: Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI
Overall structure of HHARI in complex with UbcH7-Ub. a HHARI is shown as a surface representation with individual domains labeled and color coded. UbcH7 (magenta) and Ub (gold) are shown as cartoons and the isopeptide bond linking C86K of UbcH7 to Gly76 of Ub is shown as sticks. A schematic outlining the domain organization of HHARI is shown on the bottom with regions of disorder in the structure indicated by hatched boxes. b Cartoon representation of the HHARI/UbcH7-Ub complex colored as in a. The isopeptide bond linking C86K of UbcH7 to Gly76 of Ub is shown as sticks. Zinc ions coordinated by the RING1, IBR, and RING2 domains of HHARI are shown as green spheres and the sulfur atom of the HHARI catalytic cysteine (Cys357) is shown as a yellow sphere
