Fig. 7
From: Pan-urologic cancer genomic subtypes that transcend tissue of origin
Observation of patterns associated with TCGA pan-urologic genomic subtypes in an external multi-cancer expression profiling data set. a Gene expression profiles of 341 urologic cancer cases (bladder, prostate, clear cell renal, papillary renal), represented in the Expression Project for Oncology (expO) (GSE2109) data set, were classified according to TCGA pan-urologic genomic subtype. Expression patterns for the top set of 900 mRNAs distinguishing between the nine COCA-based TCGA genomic subtypes (from Fig. 2b) are shown for both TCGA and GSE2109 data sets. Genes in the GSE2109 sample profiles sharing similarity with TCGA pan-urologic subtype-specific signature pattern are highlighted. b In the same manner as carried out for TCGA data sets (Figs. 5 and 6), expO expression profiles were scored for gene signatures related to immune cells, metabolism, hypoxia, EMT, NRF2-ARE, and Yap1. As indicated, sample profiles highlighted in red were compared with the sample profiles highlighted in blue (the comparisons being based on those carried on in Figs. 5 and 6 for TCGA data). P-values by t-test, with P < 0.05 considered as statistically significant. Parts a and b have the same ordering of expO expression profiles
