Fig. 8
Contribution of endothelial Piezo1 is vascular bed specific. Isometric tension recordings from mouse saphenous or carotid artery. a Example recordings from control genotype saphenous artery before and after application of apamin (Apa, 0.5 μM) and charybdotoxin (Ch, 0.1 μM). Phenylephrine (PE, 0.3 μM). Acetylcholine (ACh) was applied at increasing concentrations as indicated by the dots (0.01, 0.03, 0.1, 0.3 and 1 μM). b As for a but mean data (n = 5 mice). c, d As for a, b but for Piezo1ΔEC mice (n = 5 mice). e–h As for a–d but carotid artery (n = 5 control mice, n = 5 Piezo1ΔEC mice). Averaged data are displayed as mean ± s.e.m. Data sets are compared by t-test. Statistical significance is indicated by *P < 0.05, **P < 0.01
