Fig. 4

Genes differentially expressed in stroma surrounding high-Gleason grade and low-Gleason grade prostate tumors. a ssGSEA score of the stromal signature in tumor adjacent stroma; b ssGSEA score of the stromal signature in benign-adjacent stroma; c ssGSEA score of the stromal signature in low cellularity TCGA samples; d ssGSEA score of the stromal signature in high cellularity TCGA samples; e ssGSEA score of the stromal signature between indolent and lethal cases from GSE46691 cohort; f Immunohistochemical staining of epithelial ALCAM in Gleason 3 + 3 case; g Immunohistochemical staining of epithelial gene ALCAM in Gleason 4 + 4 case; h Immunohistochemical staining of stromal SULF1 in Gleason 3 + 3 case; i Immunohistochemical staining of stromal SULF1 in Gleason 3 + 3 case. P-values in (a–e) are from corresponding t-tests