Table 2 Classification of pseudoGTPases

From: p190RhoGAP proteins contain pseudoGTPase domains

Pseudoenzyme classification

Pseudokinase examples

PseudoGTPase examples

(i)

No nucleotide bindinga

VRK3, BIR2, ROR2

p190RhoGAP-A and -B pG1 and pG2, CENP-M, fungal dynein LIC

(ii)

Nucleotide binding, but with no catalytic activity

ILK, TYK2 JH2, JAK1 JH2, STRADα, MLKL

Rnd family

(iii)

Retained catalytic activity

WNK1, CASK, ErbB3, JAK2 JH2, KSR2

RGK family

  1. Examples of pseudoGTPases and pseudokinases that fit each classification are indicated
  2. aAtypical nucleotide (e.g., ATP) or divalent cation (Mn2+, etc.) binding cannot be ruled out for all examples
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