Fig. 5
From: Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1
Deletion of Vegfr3 fails to rescue coronary defects in Pofut1 cKO or Dll4 cKO mice. a PECAM1 staining and IB4/SMMHC co-staining shows increased coronaries in E16.5 heart with endocardial Pofut1 deletion, which cannot be rescued by simultaneous deletion of Vegfr3. IB4 and SMMHC co-staining shows defective major coronary arteries (arrowhead) remain in the double mutants. b PECAM1 staining shows increased coronaries in E15.5 Dll4 cKO heart by induced Dll4 deletion at E14.5, which cannot be rescued by simultaneous deletion of Vegfr3. PECAM1/DLL4 or VEGFR2/VEGFR3 co-staining shows effective deletion of Dll4 or Vegfr3
