Fig. 4
From: Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation
Physiological properties of excitable pre-OLs differ from those of OPCs. a Post-recording immunostaining of an Alexa 568-filled OPC (red) expressing NG2 (green) but not CNPase (blue). Scale bars, 10 µm. The same OPC displayed depolarizing spikes in response to current injections (60–140 pA, 300 ms) in current-clamp recordings. Inset, expanded time scale of the area within the dashed box. b An excitable pre-OL (P11) exhibiting distinct APs in response to current injections (60–140 pA, 300 ms). Inset, expanded time scale of the area within the dashed box. c I–V relationship of Iinward in an OPC (blue) and a pre-OL (black) and comparison of passive properties (capacitance and input resistance). d Relationship between spike amplitude and amount of current injected in OPCs and pre-OLs. Data represent the mean±s.e.m. *P < 0.05, ***P < 0.0001
