Fig. 2
From: Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi
Cell size and pigmentation decrease with β-catenin and cyclin D1 levels in common nevi in contrast with deep penetrating nevi. a BRAFV600E mutant common nevus. Scale bars: 300 microns, inset 12.5 microns. b BRAFV600E/CTNNB1T41A mutant DPN. Scale bars: 250 microns, inset 12.5 microns. Hematoxylin and eosin staining left and immunohistochemistry for β-catenin center and cyclin D1 right. Insets show high power views of melanocytes close to the epidermis top and in the deep dermis, away from the epidermis bottom. Melanocyte size and pigmentation diminish and β-catenin and cyclin D1 expression levels decrease with distance from epithelium in common nevus a but not in DPN b
